Frustrate the bone marrow
Frustrate the bone marrowOn the other hand, is the effectiveness of drugs, chemicals in its ability to overlap with the stages of development and the rapid growth of cancer cells, which are inherently active cells, fast growth and reproduction, which hinders its vital functions and lead to destruction, and in turn affect the drugs on some types of normal cells that grow quickly and reproduce profusely and permanent replacement, which in turn leads to the emergence of side effects associated with chemotherapy, which is one of the most important and most common, what is termed frustrated bone marrowIs the production of blood cells, various bone marrow, a spongy tissue called the spinal cord and soft red, and located within the known part bones spongy bone, and there is often in the flat bones, such as skull bone, and shoulders, and ribs, and pelvic bones, and joints arms and legs, and a key function in the production of blood cells, and consists of bone marrow cells generated by the components of the blood (hematopoietic cells), and fat cells, and tissues help the growth of blood cells and known as the cells generated blood cells counterfoil or cells of origin ( Stem cells), and are you reproduce continuously, to produce stem cells from new, it remains part of the case as cells structural generator continues to multiply, while depends partly on breeding and passing a series of transformations successive and divisions, cumulative, to mature is turned into blood cells of different ( white blood cells and red and platelets), which continues its growth and maturity stages within the spinal cord before moving on to the circulatory system to perform its functions.
(Bone marrow suppression), and which is caused by the devastating impact of drugs, chemicals on the tissues and bone marrow cells, leading to limitations on the production of critical mass of blood cells, different, and lower rates circulatory, which in turn leads to the emergence of a number of risks arising from double the effectiveness of the blood cells to the lack of population, in addition to the need to modify the dose or stop treatment until bone marrow recovery, which reduces the effectiveness of treatment against the tumor cells.
It should be noted that the types of blood cells specialized in specific functions, red blood Vkriaat (Red blood cells) contain hemoglobin (Hemoglobin), or hemoglobin that carries oxygen from the lungs to all cells of the body, and return laden with carbon dioxide, and lead to the emergence of shortages anemia, and are white blood cells (White blood cells) the key element in the body's immune system, and specializes in attacking foreign objects such as bacteria or viruses, and fighting infection, and cause shortages in the weakness of the immune system and lead to easily pick up infections without the estimated the resistance, while playing a platelet (platelets) the main role in the operations of blood clots, which lived up wounds or cuttings, or tears in any position of the body and stop the bleeding, and result in shortages to the loss of the ability to clot blood, and therefore easy bleeding for the slightest reason and in any position, including the vital organs of the Interior.
The blood cell life-spans of varying and specific circulatory wear out after and ends, and are replaced by new production from the bone marrow continuously and constantly, with an average age of white blood cells about six hours, while the average life span of platelets about ten days, The red blood cells, live in average about 120 days.
It is worth mentioning that the population of blood cells, circulatory does not decline immediately after starting to receive doses of chemotherapy, since the drugs do not directly affect the blood cells in circulatory, while affecting contrast to the tissues of bone marrow producing blood cells, and cells deficient which still going through phases of birth and rapid growth, and cause their destruction, which ultimately leads to frustration and spinal disability for the production of new blood cells.
And the end of the life of blood cells in circulatory, and the inability of the bone is frustrating for the production of alternatives, starting blood cell count to drop to critical levels, and over varying periods of time, (depending on the type of property is the chemical used and dose of course), and continue the status frustration and falling rates of blood cell count until the bone healed and his return to the pace of normal production after the passage of varying periods of time.
And from here called the lower level of blood cell count reached him frustration at the spinal level of scarcity (nadir), and count up every type of blood cells to this level during the varying periods after receiving treatment, as it might a white cell count and platelet levels during periods of scarcity ranging from 3 to 7 days and sometimes within 14 days, while it may inform him of the red blood cell counts during several weeks, as they live longer.
On the other hand is permanently analysis of periodic different blood when receiving chemotherapy, from which blood cell count total (complete blood count CBC) and sometimes on a daily basis, to monitor the effects of drugs on bone marrow, and fluctuations in the rates of blood cells, (as may be draw samples from spinal to examine the cells that produce blood cells), and of course, a patient in a critical situation when they reach the censuses of the level of scarcity, and take actions necessary medical and preventive, including the amendment of therapeutic doses downwards, postponed or suspended until the return rates to the levels appropriate, and is worth mentioning that the clinical studies of many tumors may show that recovery rates lower among the patients, while forcing physicians to reduce therapeutic doses or postponed for extended periods of time, because of the complications frustrate the core, while the rise when patients can receive doses in full, and by scheduling of specific therapeutic plans.
And in the following paragraphs we review the profile from the complications of bone marrow frustration resulting from the use of chemical drugs, the effects of the shortage in the rates of blood cells, which include the emergence of anemia (Anemia) in the patient, and the emergence of destitution of white blood cells
(Leukopenia), and the case of deficiency of blood platelets (Thrombocytopenia).
