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Soft tissue sarcomas

Introduction



Algarnih soft tissue tumors or soft (Soft tissue Sarcoma), cancerous tumors are classified as sarcomas Algarnih (sarcoma), and the body's soft tissues arise, and is the tissue that connects the structure and organs of the body, supported or surrounded by, and include muscle and tissue macrophages, such as the tendons that connect muscles to bones, and fibrous tissue and cartilage, and Synovial tissue around the joints (synovial tissues), in addition to fat, and blood vessels, nerves, and these tumors may arise and grow in any position of the body, but arise when children develop normally and torso area (chest, back, abdomen, pelvis, shoulders) and limbs (arms, hands, legs, feet), and may arise in a small percentage area of ​​the head and neck.

And there are many types of these tumors, which are classified as soft tissue sites arise, and show a species that occur in children often planned and smooth muscle, and connective tissue, and blood vessels and lymph nodes, and peripheral nervous system, and is Algarnih muscle tumors Planned (Rhabdomyosarcoma) that arise muscle structural voluntary surrounding bone, the most common type in children, and it should be noted that some of the medical literature refers to tumors of soft tissues in general, as two parts, tumors Garnih muscles planned, and tumors Garnih not muscle Planned ( Nonrhabdomyosarcoma) referring to all tumors of soft tissues, except muscle tumors arising Algarnih planned.




About risk factors for the emergence of soft tissue tumors



The term risk factors (Risk factors) to the factors and conditions that increase the likelihood of vulnerability to any disease, such as cancer, when any person, and there are risk factors for each type of tumor, and may include risk factors and genetic any associated characteristics of genes, in addition to factors linked to the environment or lifestyle and living conditions, and although the factors on the pattern of living, such as smoking and poor nutrition or alcohol consumption are important factors in many of the tumors in adults, but its impact is none or weak when dealing with tumors of children, and with regard to risk factors on the environment, not clear to researchers of any link between the emergence of tumors of soft tissue in children and between environmental factors either before or after the birth, such as exposure to toxic chemicals or contamination of water and air, also did not prove the existence of any link to other conditions, such as the use of X-rays during pregnancy, or address the types of different drugs, or injury to children bruises frequent or wounds, and on the other hand there are studies that are not installed between the emergence of these tumors in children and among a number of different factors, such as the low standard of living, and exposure of embryos to ionizing radiation, and the abuse of parents drugs.

It is worth mentioning that some studies link the development of these tumors in adults and between the constant exposure to some chemicals, most notably acid phenoxy acetic (phenoxyacetic acid) used in the manufacture of herbicides and chlorophenols (chlorophenols) are used as preservatives in the wood industries, as well to vinyl chloride (vinyl chloride) used in the plastics industry and which was attributed to him in particular Algarnih tumor blood vessels (angiosarcoma) of the liver in some cases adults.

Risk factors related to ionizing radiation:

According to many medical studies for a direct relationship, and by minimal risk, the treatment of cancer patients, whether adults or children, radiation therapy, and between the appearance of secondary tumors is the original tumor processor during the later periods of life, including the emergence of some types of tumors, soft tissue placements located within the field of radiation therapy (and if a small percentage), which increases risk of its development when receiving treatments in the periods of early life as well as receiving high doses, and is of such secondary tumors are more common in adults, where they appear after several years (up to thirty) of the end of radiation treatments.

It should be noted that, and at the beginning of the last century, where scientists are discovering the potential of ionizing radiation-use treatment, has been addressed many diseases other than cancer radiation (such as inflammation of the tonsils and adenoids), without being able to determine doses safe and ways to focus the radiation, and may later studies reported the emergence of some types of soft tissue tumors in some patients as a result of that, and at present envisages radiation treatments for cancer, the utmost care in the shed on the subject of radiation oncology maximum accuracy, while protecting healthy tissue as possible.

Genetic risk factors and the ills of genes:

Found to scientists for decades, that man may inherit from parents on some changes and imbalances blades genetic DNA of the cells, which in turn cause disease spread in the family-specific, and there is the proportion of high risk for many diseases at the birth of children with some types of birth defects and known Palmtlazmat (syndromes and the syndrome can be defined as a set of concurrent symptoms and deformities or disabilities or other anomalies, which appear in most cases combined in the same patient), and the syndromes that have been linked with an increased rate and severity of the emergence of soft tissue tumors:

Syndrome Beckwith, and Weidman (Beckwith-Wiedemann syndrome): where the growing internal organs, such as the liver and spleen, in children with this syndrome sizes are enlarged and unusual, and shows that the tongue is common, and the usual also appear, including bug over-large mid-term ( hemihypertrophy), swelling of the arm or a man or both, one side of the body, in addition to the non-uniformity in physical growth, and although the children with this syndrome are highly vulnerable to the emergence of Wilms' tumor of kidney in particular, but they carry the risk for a lesser extent for the emergence of tumors Algarnih of the muscles planned within the soft tissue.

I Fraomena syndrome (Li-Fraumeni): in addition to which it increases the level of risk for the emergence of tumors, leukemia and bone tumors Algarnih and breast cancer and brain tumors, also carries the risk for the emergence of soft tissue tumors, especially tumors of striated muscle.

Bug neurofibromas (Neurofibromatosis), and also known illness Ericlengahaozn
(Recklinghausen's disease), and are the reasons for a genetic characterization of the emergence of tumors of the fibrous nerve terminal, and the appearance of brown spots on the skin and deformities tissue under the skin and bones, and the usual cause of this malady in the emergence of tumors of neural multiple, but they also increase The risk of the emergence of soft tissue tumors, including tumors of striated muscle Algarnih.

It should be noted that these illnesses and syndromes are rare and represent a small percentage of cases of soft tissue tumors, while not know a specific reason behind the emergence of such tumors in other cases do not suffer from such ills.










About the emergence of soft tissue tumors



We need to understand how the emergence of cancer cells, knowledge of some basic information about the genetic characteristics and genes (genes), Valmorth is a part of the DNA Alrebonowi (deoxyribonucleic acid DNA) carries the characteristics of specific genetic and has a vital function specific, and an example set of genes color of the eyes and skin , or blood group, and this acid is a chemical that carries instructions for the system and the life cycle of cells, and the control of all its activities, and is the type of changes anomalies in the DNA of the genes influencing factor in determining the type of disease that may affect humans, and genes are parts of chromosomes (chromosomes), which can be likened to a band of linear DNA Mazfor high length, containing thousands of genes lined end to end, and the DNA is organized strictly in the 23 pairs of chromosomes, inherits half of each pair from one parent .

And there are multiple types and so many of the genes, and each of them vital functions and characteristics of specific genetic, and contains some of the types of instructions and codes of genetic control in the mechanism of growth and division, and thus replication and reproduction for the production of new cells, and from these genes of certain urges and modify operations cell division, called idiomatically genes tumor (oncogenes), and genes other slow and inhibit the division and reproduction, or give instructions to the annihilation of the self-cell, when needed, and called genes inhibiting the swelling (Tumor suppressor genes).

And other words, the cells multiply and divide and grow under the guidance of the program is encrypted Bhamadha nuclear, and receive a signal to stop at a certain point where the available amount desired of cells, depends divide and multiply, and run programs next directed the cells to produce proteins necessary for the cells become very able to carry out the tasks entrusted to it, ie, that the system of division, growth and employment, stops and starts and is active as a sequential staggered, and free of errors to produce normal cells intact, and there are many ways to block and district progress of this system systematically, for example, if deficiencies in the signal to stop and did not work for some reason, continue to the cells to divide and multiply unchecked and the mass of abnormal enlarged, or when a failure in the work of genes inhibiting the swelling, which produces a certain protein is responsible for the arrest of the cell when there is damage to DNA, whether to fix bugs or to exterminate self when you can not reform, when not working this protein for some reason, continue to cells with DNA dysfunctional in the division, and production of new cells, causing more damage in genes other, which control the growth and development of cells and end up with the emergence of cancer, and such failure is responsible for the high level of risk for the emergence of many tumors, and including some tumors, soft tissue, in the cases of acquired me Fraomena (Li-Fraumeni) above, which arise from the inheritance of disruption of DNA leads to frustration gene brake swelling of the known Palmorth my 53 (p53 tumor suppressor gene) and therefore frustrate the proteins responsible for the arrest of the cells to repair DNA damages and to prevent defective cells from growing, as well as with illness neurofibromas appear as imbalance Palmorth named n. P 1 (NF1).

On the other hand may inherit one some of the changes the anomalous (or defects), DNA from his parents, which explains the appearance of some illnesses are common in some families, and including the syndromes mentioned above, and called these changes Balthorat or changes the root of the structure (mutations) , which also arise for reasons that are incomprehensible and unjustified imbalance just like the other images that affect this acid, which can be summarized in the following points:

Sherrod chromosomes and exchange sites (Translocation) between the two parts of the DNA, that is, a section of DNA Besbga a homeless HOS Besbga different and asymmetric with him, leading to rearrange programs encoded DNA of the cell with the stability of error and system crashes, context-oriented for the different stages, and this imbalance in particular is responsible for the emergence of some types of tumors of children, such as certain types of leukemia, and many soft tissue tumors.

Reflection or the coup (inversion), which means that part of the chromosome is inverted, and overlay in reflected light it is still linked to the same chromosome.

Addendum (addition) of any part of the chromosome (chromosome or the whole) has doubled and many copies of it are located the cell, and is referred to with reference number chromosome positive (+7, for example).

Loss or erasure (deletion) of some of the clips DNA Besbga specific, and referred to as the chromosome number with a negative sign, eg -7 means that there is a missing part of chromosome VII.

And from here can Ttsrtun normal cells at any of the above-mentioned types of imbalance structure of DNA (ie, mutations or abnormal structure of chromosomes fugue or a reversal or erasure or addition), which in turn paid (directly or indirectly) to run the testator tumor without controls (which lose the ability to control cell growth and reproduction), or invalidate the work of genes inhibiting the swelling, and end up with the emergence of a cancerous tumor, and it is important to know that, and except for genetic disorders that increase the level of risk for the emergence of some tumors, no Scientists know the real reasons and confirmed that lead to an imbalance types of DNA, (which trigger or trigger) and that lead to carcinogenesis of normal cells and tumor.

In terms of tumors, soft tissue, according to medical studies about the existence of some types of imbalance, which is directly responsible for the emergence of such tumors, we recall, for example, the presence of the exchange sites between chromosome XII and XVI-cell tumor of lipomas mucous (Myxoid liposarcomas), and the emergence of the exchange sites between the chromosomes and the ninth to the twenty-second and cartilage tumors Algarnih mucous out of the bones (Extraskeletal myxoid chondrosarcoma), while showing the exchange between Abbgan X and XVIII of synovial tumors Algarnih (synovial sarcoma), as there is exchange between sites chromosomes II and XIII in most cases the tumor alveolar tumors Algarnih muscles planned (rhabdomyosarcomas) in addition to a loss of some of the clips DNA Babbga atheist tenth when cases of tumor of fetal tumors mentioned, and on the other hand there is doubled for the same chromosome cell tumor with tumor Algarnih fibroblasts (fibrosarcoma).

It should be noted that research confirms that these mutations and exchanges abnormal and associated with the emergence of many tumors of soft tissue are glitches acquired and casual after birth and during the stages of children's lives, and not shifting the inheritance, and indicate that there is no cause of clear or risk factors known and tion lead to uncertain, and therefore there was no what can be done to avoid the emergence of cancer.



About the symptoms and diagnosis



May not result from tumors of soft tissue of any obvious symptoms and the phenomenon in its early stages, as the soft tissues soft and flexible, allowing the tumor to expand growth Maziha these tissues before swell even cause complications and are seen, while showing symptoms of the initial striking of the attention usually in the form of swelling or mass of overgrown position of the tumor, without accompanying pain or problems with side effects, and especially if the concentration of the tumor in the trunk or limbs, and may show pain or sores at the tumor growth and inflation and pressure on adjacent nerves or muscles, and the overlap with the functions of the body may produce other symptoms, and is not usually show symptoms of physical public, such as fever, weight loss and night sweats, with most tumors, soft tissue, only when there is a transition of the tumor from the position of its inception, and in this case it may appear like symptoms leukemia, such as swollen lymph nodes or bone pain or fatigue or loss of weight, which gives an indication on the movement of tumor cells to the lymph nodes or bone, and on the other hand may show some problems in the lungs and clear in the early stages of transmission of tumor cells to them.

When you see the symptoms on the child, which can indicate the presence of any of the tumors, soft tissue, the doctors conducted numerous tests and laboratory tests to determine the various aspects of the growth of the tumor accurately, and conduct imaging studies of different, such as tomography (Computed tomography scan), Planning MRI magnetic (Magnetic resonance imaging using radio waves, magnetic to put multiple images of the body), in addition to planning the bones and take X-ray images of various, including x-rays to Sadr to investigate the extent of transmission of tumor cells to the lungs, is also an analysis of different blood, in addition to the census whole blood, which will explain the transmission of tumor cells of the bone marrow, of course, is a blood and urine tests that explore the functions of the liver and kidneys, and measuring the ratios of salts in the body.

On the other hand, and although the symptoms and tests soundtracks of various types could clearly confirm the presence of tumors, soft tissue, but the only way to be absolutely sure, and then differentiate these tumors from other tumors like, and characterization of the vital precisely , is a surgical osteotomy (biopsy), which aims to extract a biopsy of the tumor tissue to be examined microscopically.

(Please go to a page that tests and laboratory tests to see more details about the aspects of these tests).










Classification of tumors of soft tissue



As is usual with the various types of tumors, are classified as tumors of soft tissue according to classification systems of the progress of the tumor (staging) and through the extraction of data from tests and laboratory tests and imaging, in addition to testing the direct tumor tissue, and any tissues derived following the surgery, in order to determine the size of the tumor and its properties vital, and ascertain the extent of his move from the position of its inception to the surrounding tissue or to any other sites, and determine the amount the cancer is located and body positions concentration and area of ​​spread, it is necessary to know these facts and determine the classification for planning treatments and to explore evidence on cost-effective treatment possible.

And rolling for soft tissue tumors classified according to their positions and the transition into two categories:

Topical administration, confined tumors, and tumors transmitted and dispersed, in addition of course to the recurrent tumors after treatments.

Almnhsr tumor or circulating (Nonmetastatic)

Included in this category placements administration, confined tumors arise and formed the original, without moving to other body sites, and of course, this category is divided into two types, administration, confined tumors viable surgical resection (resectable), and administration, confined eradication impossible (nonresectable).

Circulating tumor or Almenbt (Metastatic)

And include in this category, moving from positions of tumors to arise elsewhere in the body, lungs, and is one of the most moving places and the emergence of secondary tumors in most cases.

Recurrent tumors (Recurrent)

This classification means that the tumor had returned, and a back, or went too far and become resistant after it was processed, and may return in the same place of origin, where he began, or the surrounding tissue or another body back position.









On the treatment of soft tissue tumors



There are treatments for all cases of this type of tumor in children, and most of them are curable to varying degrees, and the dependent child's chances of recovery and treatment options on several factors combined, the most important position of the tumor and the extent of concentration, and vital cells, and classified and how he moved out of position Growing the original, and its interaction with the treatments, in addition to the child's age and general health condition, and usually follow the standard treatments that have proven their effectiveness.

And targeted treatments, of course, to cure with the effort in maintaining the functions of the infected parts whenever possible, in addition to reducing the complications of different treatments to the minimum possible, which calls for the need for the treatment center specialist tumors of children and the involvement of a team of specialists to manage the plans treatment, ranging from surgeons and specialists Oncology and Radiotherapy, and Pathology and specialists in natural treatments and rehabilitation, in addition to social workers and nursing staff who specializes in treating children with cancer patients.

As is the case with solid tumors, is a surgical process line initial and primary tumors of soft tissue, combined with the use of radiation therapy with chemotherapy with or without, but the treatment plans may vary of course depending on the situation and the type and classification of the tumor and according to the factors mentioned above.



Surgery

A surgery where possible to eradicate as many as possible of the fabric of the tumor and some healthy tissue surrounding the position, followed by a start radiation therapy with the use of chemotherapy with or without, and may use surgery after these two treatments to remove any remaining tumor, and in case of presence tumor prevent placement of surgery and can not eradication, is limited to surgical work on the extraction of tissue biopsies examined.

And options depend surgery on the type of tumor and its position and how that will affect the surgery on the function and effectiveness of the injured part of the body, many of the tumors that arise tissue soft and some types of bone, which positioned parts of non-core body can be removed without causing a disability or disabilities, While not eradication total to each other, such as that shown Baldhirain and legs, without affecting the effectiveness of a patient, and during the past decades, amputation is the option available for the treatment of such tumors, but in this time has made processors surgery, so they can remove large parts Parties and bones and replacing vaccinations bone, or sheets, metal rods, or alternatives to industrial (prosthesis), such as bones and joints made of plastics or metals, to make up for the part that has been eradicated with the tumor, known as the surgery salvage Members (Limb-salvage surgery) , and such surgery complicated course and require a several operations and months of physical therapy until the child can use a patient effectively, and in some cases may be unable to perform the surgery replacement for several reasons, such as the presence of tumor bone is difficult to replace, or extend tumor to nervous tissue or blood vessels key can not be removed without causing substantial user barbed injured, and here is handled such cases, radiation therapy and chemotherapy instead of surgery.

(And please go to surgery to see more details about the surgical aspects of the work).










Radiation therapy



Radiation therapy is the treatment using the different applications of ionizing radiation (ionizing radiation), to destroy cancer cells and shrink tumors, both using the elements and isotopes, or by using a stream of radiation, revived and high-energy, x-rays, or radiation such as gamma rays, or stream of neutrons or protons, and the effectiveness of the radiation is concentrated in its ability to undermine and break up the DNA of tumor cells, and is a vital and fundamental article of the various cellular functions, leading to elimination.

Radiation therapy is topical treatment, and is divided into two types; internal (Internal), radioactive elements are grown directly into the tumor tissue, or close to it, either temporarily or permanently, and external (external), where the broadcast radiation from the radiation machine shed the positions of the tumors, and may be used both types in some types of tumors, and of course, and to avoid the effects of radiation, is to take preventive measures during radiation therapy, to protect tissues and organs natural sound field processing.

And may be the use of radiation therapy alone, treatment only, or jointly with treatments other tumors, and may use a substitute for surgery as initial therapy, when some solid tumors, may also be used by the direct action surgical known as the treatment initial Assistant (neoadjuvant therapy), order to reduce the size of the tumor; to facilitate the eradication, or is used after excision surgery as a treatment additive (adjuvant therapy); in order to eliminate any tumor cells is characteristic may be outstanding.

And, of course, for the treatment of radiation complications and side effects associated with, linked to the overall locus of treatment, and result in general from affected cells and tissues rapidly growing and replacement, and from these effects: complications of skin and skin, and fatigue, and infections and dry mouth, and hair loss, nausea, gastrointestinal problems, and thwart the bone marrow, and is taking some preventive measures and support, and taking medication assistance; to avoid such effects and to alleviate it.

(Please go to radiation therapy, to view more details).










Chemotherapy



Chemotherapy is the treatment using special drugs known drug chemical anti-cancer, the elimination of cancer cells and destroy them, and so disrupt and undermine the coordinated biological processes within them, and come the main advantage of this treatment in his ability to deal with tumors of mobile and deployed, whereas the radiation therapy or work on the surgical treatment of specific placements administration, confined tumors, its effectiveness and unique due to the fact that cancer cells, in a way, is more sensitive and more susceptible to chemicals than normal cells. And may be used as a treatment only in some cases, or part of a treatment program integrated includes several treatments in common, and decision-making by using this treatment, the balance between effectiveness and side effects and complications of the future, and between the seriousness of cancer, and of course Vamadaafath and its acceptable compared to the same disease, in addition to the positive therapeutic yield significantly.

And may be called the chemotherapy treatment systemically (systemic); due to movement of drugs, chemicals via the blood to all parts of the body, and its ability to destroy cancer cells wherever notified, and may be used before the direct surgeries when solid tumors preparation for her and in order to facilitate; Bhzareth and shrink the tumor, what is known as chemotherapy Initial Assistant (Neoadjuvant), may also be used after surgery and eradication of the tumor; to eliminate any cells of a tumor is characteristic may be outstanding, and help avoid the return of cancer, what is known as chemotherapy additive (adjuvant).

And be dealt with chemotherapy drugs in ways and different channels, some of which are taken orally in the form of tablets or capsules or liquids, and most of the body is injected, the injection of different ways: by intravenous injection, intramuscular injection, injection into an artery or a major injection topically directly under the skin, and if intravenous is the most widely used method, and may use other means to assist in the injection, such as catheters (catheters), which is implanted usually chest and can be used for long periods, and is injected drugs directly into the spinal fluid cerebrospinal surrounding the spinal cord and brain, known as the injection vaginalis, both to eliminate tumor cells, or to protect the central nervous system and brain, and is usually injected through the lumbar spine down the spine, or via a catheter especially planted under the scalp known as portfolio Omaya ( Ommaya reservoir).

And usually consist of treatment programs from several repeated cycles separated by periods of recovery, and may receive the patient during each session, a combination common in many medicines chemical, or are limited to one drug, by type of tumor and the planned therapeutic approach in each case, and in general are the use of chemotherapy during the time periods prolonged to reduce how much the cancer cells gradually, to the extent that it could when the immune system control of any growth and throw, in addition to that space of time between doses are placed in order to achieve the greatest effect on cancer cells, and at the same time give the sufficient to allow cells and tissue normal to recover from the effect of drugs, chemicals, since the types of drugs of different effects to varying degrees on the cells and organs of natural sound, especially the cells and tissues fast-growing and heavy reproduction and a permanent replacement, such as bone marrow cells and blood cells, and cells and tissues of the digestive system, in addition to some vital organs like the liver and kidneys, which in turn leads to complications side effects, which vary in intensity and quality of the drug to another and from one person to another, and of course of treatment to another even for the same person , and depend mainly on the type and dose of the drug user and the interaction of the body about it, and these effects are multiple; frustration include bone marrow (and thus decrease blood cell count), and complications of the mouth and gums (such as inflammation and ulceration, and drought), and hair loss temporary, constipation, diarrhea, and fatigue, nausea, vomiting, loss of appetite, and feel the skin and skin, and usually take drugs to help and take some preventive measures and support; to avoid such effects and to prevent them and to alleviate it , before and during treatment sessions and after termination.

(Please go to chemotherapy, to view more details about this treatment and methods of its management and its complications).









On the processors according to the classification tumor



Almnhsr tumor and non-signing

Course of treatment depends on the type of tumor, and for tumors such as Sarcoma fibrous, and tumor cells, textile fiber, and Algarni vascular tumor, the treatment plan may consist of the following:

Surgery to remove the entire tumor tissue, and sometimes it requires surgery next, whether to ensure full eradication of the tumor, or when tumor recurrence after receiving treatments.

Surgery to remove the tumor tracking radiotherapy, (that could not be made the second surgery).

Assistant initial chemotherapy to reduce the size of the tumor followed by surgery.

And clinical studies are underway to evaluate novel combinations of chemotherapy drugs to treat these tumors.

As for tumors such as tumor nerve fibers, Algarni synovial tumor, histologic tumor cells, smooth muscle tumor, Valmaaljh may be one of the following options:

Surgery to remove the tumor and sometimes it requires surgery to make sure the next full eradication of the tumor.

Surgery with radiation therapy (if not totally eradicate the tumor with surgery).

And for tumor parties Valmaaljh alveolar nerve is usually one of the following treatments:

Surgery to eradicate the entire tumor tissue.

Surgery to remove the tumor followed by radiation therapy (if not totally eradicate the tumor with surgery).



And circulating tumor Almenbt

Than usual to have children who suffer from tumors of soft tissues in transition, treatments joint consists of two treatments chemotherapy and radiation and surgery, including lumpectomy Almenbt to the lungs, and clinical studies are underway to evaluate the effectiveness of combinations of chemotherapy and incentives development, for patients who did not undergo for surgery or have secondary tumors crossover.



Address the recurrent tumor

May occur relapse and recurrence in the short-term or after the passage of years from initial treatment, and when you return is a comprehensive assessment of the situation, to determine how focused the tumor and the area of ​​presence and degree, and adopt the treatment plan depends on several factors, notably the position of the tumor and whether the returned in the same position of its inception, the first or the locus of another, and the amount can be removed surgically, in addition to treatments that were followed in the past, may be an additional surgery to eradicate the many as tumor tissue, or surgery followed by radiation therapy (that did not receive the patient's radiation in the past ), and may resort to the amputation of tumors of the Parties in cases that have received radiation therapy previously, and this occurs in less than 10% of such cases, and clinical studies are still underway to assess the effectiveness of new chemotherapy combinations.










After the treatments



Necessary to conduct tests periodically comprehensive last for several years after the end of treatments, in order to investigate any signs of the return of tumors of soft tissue or movement, or the emergence of new tumors, as well as to monitor complications and side effects of different treatments received, whether immediate or delayed, which may appear years after (please go to a page of late complications of treatments for tumors to see more details), and include these tests in addition to clinical examination of flour, measuring growth rates, lab tests types and imaging studies and X-rays of different, especially for the position of the tumor and the lungs, and are made to schedule a specific time vary according to each individual case, and (than usual in all cases, some imaging studies per month during the first six months and then every three months the first year and a rate of less than later years).

It is very important, of course, be notified of the medical team in the case when the appearance of any symptoms or complications of a new, which may indicate the occurrence of relapse and a return to growth tumor, or indicate the presence of complications and side effects of treatments received, in order to take action necessary medical early.
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